Harnessing the therapeutic power of altitude

Hypoxia inducible factor (HIF) biology mimics the body’s protective physiologic response to altitude—with powerful promise in the treatment of serious disease.

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Denver, CO

Vadadustat (also known as AKB-6548) mimics the physiological response to modest elevation—like that of Denver, CO


The 2016 Albert Lasker Basic Medical Research Award honors three physician-scientists for their discovery of the HIF pathway.

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What is HIF?

Harnessing the power of altitude in the treatment of serious disease. Learn more »

Our Pipeline

Pursuing indications in kidney disease and other serious conditions. Learn more »