Hypoxia inducible factor (HIF) enables the body’s adaptive physiologic response to altitude—and has great promise in the treatment of serious diseases.

Learn how we’re leading the way


So What is HIF?

HIF helps the body to adapt to conditions of low oxygen, similar to what is experienced at moderate altitude. Learn more about the potential therapeutic value of HIF.

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Akebia is growing! See what being a HIFSTER is all about.

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Our Pipeline

We're Pursuing indications in kidney disease and other serious conditions.

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The Science of High Altitude

We're Exploring the Link Between Hypoxia and Treatment of Serious Diseases.

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2016 Albert Lasker award recipient

2016 Albert Lasker AwardThe 2016 Albert Lasker Basic Medical Research Award honors three physician-scientists for their discovery of the pathway by which cells from human and most animals sense and adapt to changes in oxygen availability, a process that is essential for survival. Scientists had long appreciated that the success of today's dominant life forms hinges on oxygen, yet little was known about their responses to it. Read more »